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In locally advanced pancreatic cancer, neoadjuvant chemotherapy is usually given before surgery, followed by chemoradiation. Recently, a limited number of studies have shown positive results on survival in locally advanced pancreatic cancer patients who receive a chemoradiotherapy, especially if an isolated high-dose radiotherapy was added as a boost. The aim of this study was to evaluate the efficacy of the above strategy in terms of toxicity and survival in a prospective cohort study. In this study, from April 2001 to November 2005, 80 patients with locally advanced pancreatic cancer were enrolled. All patients underwent a palliative first-line chemotherapy (FOLFIRINOX) followed by a SBRT boost and, subsequently, an adjuvant daily administration of interferon α for 1 year. The median follow-up time was 24.9 months (range: 6.2-59.4). After a complete response was achieved, 27% of the patients were operable. The median overall survival was 19.1 months (range: 2-60). The median survival for patients with metastatic at presentation was 15.6 months (range: 2-59) and for those with resectable disease it was 23.6 months (range: 6-59). The median survival for patients with metastatic disease at the beginning of treatment was 11.5 months (range: 3-36), which was significantly longer than the one for patients with metastatic disease at baseline (p=0.008). No treatment-related deaths occurred. This study suggests that, in patients with advanced disease, surgical management is feasible after neoadjuvant treatment and radiotherapy boost. A longer follow-up time is necessary to assess the efficacy of this treatment.
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